Everybody knows acne and 80% of us are or were affected by this disease, with more or less severe consequences for our well-being.

Summary

Everybody knows acne and 80% of us are or were or will be affected by this disease

with more or less severe consequences for our well-being. Despite the worldwide distribution and high frequency of acne, no efficient treatment is available (except from drugs with substantial side effects). Decades of research have not resolved the exact mechanisms of acne disease formation.

Our research team and other research labs worldwide have recently shown that acne-affected skin differs from healthy skin in terms of the associated microorganisms, the so-called skin microbiota (see "Articles"). The skin microbiota of healthy people and acne sufferes differs. One main difference is a bacterium called Propionibacterium acnes (P. acnes): different types of this bacterium exist on our skin and healthy skin-associated types differ from acne-associated types.

Healthy skin carries different types of P. acnes than acne-affected skin.

We propose to take advantage of these recent research findings, by replacing the acne-associated skin microbiota with the microbiota from healthy skin. To shift the balance we will suppress specifically acne-associated P. acnes bacteria and support the health-associated microbiota.

Anticipated outcome: A tailor-made drug that will inhibit the acne-associated portion of the skin microflora and that will support the normal, health-associated microflora. To achieve this we will use the health-associated types of P. acnes in a probiotic-like approach to colonize and out-compete the acne-associated types. 

 

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