Everybody knows acne and 80% of us are or were affected by this disease, with more or less severe consequences for our well-being.

Selected scientific publications from our P. acnes research

see also: the lab website 

 

Lomholt HB, Kilian M. (2014) Clonality and anatomic distribution on the skin of antibiotic resistant and sensitive Propionibacterium acnesActa Derm. Venereol. 2014 Feb 27.

Mak TN, Schmid M, Brzuszkiewicz E, Zeng G, Meyer R, Sfanos KS, Brinkmann V, Meyer TF, Brüggemann H. (2013) Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria. BMC Genomics 14:640.

Kilian M, Scholz CF, Lomholt HB. (2012) Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes. J Clin Microbiol. 50:1158-65.

Fischer N, Mak TN, Shinohara DB, Sfanos KS, Meyer TF, Brüggemann H. (2013) Deciphering the intracellular fate of Propionibacterium acnes in macrophages. Biomed Res Int. 2013:603046. 

Brüggemann H, Lood R. (2013) Bacteriophages infecting Propionibacterium acnes. Biomed Res Int. 2013:705741. 

Mak TN, Fischer N, Laube B, Brinkmann V, Metruccio MM, Sfanos KS, Mollenkopf HJ, Meyer TF, Brüggemann H. (2012) Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation. Cell Microbiol. 14:1720-33.

Brüggemann H, Lomholt HB, Kilian M. (2012) The flexible gene pool of Propionibacterium acnesMob Genet Elements 2:145-148.

Brüggemann H, Lomholt HB, Tettelin H, Kilian M (2012) CRISPR/cas loci of type II Propionibacterium acnes confer immunity against acquisition of mobile elements present in type I P. acnes. PLoS ONE 7, e34171.

Lood R, Collin M. (2011) Characterization and genome sequencing of two Propionibacterium acnes phages displaying pseudolysogeny. BMC Genomics 12:198.

Brzuszkiewicz, E., Weiner, J., Wollherr, A., Thürmer, A., Hüpeden, J., Lomholt, H.B., Kilian, M., Gottschalk, G., Daniel, R., Mollenkopf, H.-J., Meyer T.F., Brüggemann, H. (2011). Comparative genomics and transcriptomics of Propionibacterium acnes. PLoS ONE 6, e21581.

Holland, C, Mak, TN, Zimny-Arndt, U, Schmid, M, Meyer, TF, Jungblut, PR, Brüggemann, H (2010) Proteomic identification of secreted proteins of Propionibacterium acnes. BMC Microbiol. 10, 230

Lomholt, HB, and Kilian, M (2010) Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. PLoS ONE 5, e12277.

Holmberg A, Lood R, Mörgelin M, Söderquist B, Holst E, Collin M, Christensson B, Rasmussen M. (2009) Biofilm formation by Propionibacterium acnes is a characteristic of invasive isolates. Clin Microbiol Infect. 15:787-95.

Lood R, Mörgelin M, Holmberg A, Rasmussen M, Collin M. (2008) Inducible Siphoviruses in superficial and deep tissue isolates of Propionibacterium acnesBMC Microbiol 8:139.

Brüggemann, H. (2005). Insights in the pathogenic potential of Propionibacterium acnes from its complete genome. Semin Cutan Med Surg 24, 67–72.

Brüggemann, H., Henne, A., Hoster, F., Liesegang, H., Wiezer, A., Strittmatter, A., Hujer, S., Dürre, P., and Gottschalk, G. (2004). The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science 305, 671–673.

 

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